Hey kbnet...they're going well. I'm up to 13 of them.

Sophos is pretty great. I've had it deployed since last week and it has not been infected once. I was using 3.89 but now I have 3.90 deployed. The interface is pretty blah...it is designed to be managed by their central server. I do have a tip though, if you would like to run it on a single box you can get this script to update it automatically...just set it up in task scheduler or create a batch that you whack every day or so:
http://updatesophos.sourceforge.net/I've been doing this since October and I've considerably upgraded my setup since then. Now I have two beefy Linux servers running VMware systems and one hardened Windows box storing my samples and analysis tools. The network is completely DMZ'd from the rest of my stuff and I have QoS, Snort, and full network logging enabled for forensic analysis cross-checking (since I use tools on the host to analyze the worms, etc.).
Anyway, my opinion is high on the following products:
Kaspersky (in general)
McAfee (VirusScan Enterprise 8.00)
Sophos (in general)
Dr. Web (desktop AV)
F-Secure (since they're Kaspersky JR.)
I'd *almost* put VirusBuster up there. They've impressed me but they have been infected a time or two since deployment last week. Could just be luck..but who knows. The above names have not yet been infected and generally thwart everything.
Also, Kaspersky has seemed to fix it's sometimes buggy code if you are using their Personal Pro or Business Optimal versions. If you use just regular ol' Personal (or Defender Pro 2005 like I was) - you can have buggy issues. Makes sense I guess, since the Personal Pro/Business Optimal versions were only recently updated and the Personal version was out for several months before them. Perhaps that is how they beta test.